Yes, there are multiple models ranging in capacities from 250 g to 20 Kg. MEDISCA has selected the KK-300SS as its benchmark model, as it is suitable for most compounding practices. All models use the same planetary mixing technology with mixing / deaerating settings optimized for each. MEDISCA is exclusive for the entire line of MAZ mixers and can source any model required.

Mixing creams / gels / ointments:
- Compounded preparations with hormones.
- Multi-API formulations.
- Low concentration API formulations.
Mixing liquids:
- High-viscosity liquids which are normally difficult to mix or which require long processing time by conventional mixing machines.
- Suspensions: Mixing liquids and powders, which need to be evenly mixed even if their characteristics and specific gravities are widely different.
Deaeration:
- With its built-in vacuum-like feature (degas mode), you can remove entrapped air, resulting in a beautifully elegant product for the pharmacist, and accurate dispensing of the medication for the patient.
Melting:
- The rotation of the unit for 3 minutes generates enough heat to melt Gelatin Gum Base at a max temperature of 50oC.
Milling: - Adding the Zirconia milling beads with a stainless steel liner will allow you to micronize your powders thus replacing the process of trituration.

Given its high G-forces, the MAZ mixer can thoroughly mix powders, but in limited quantities. For the KK-300SS, a maximum of 25 g can be thoroughly mixed in 30 seconds at 1,500 rpm. For optimal and effective mixing of larger amounts of powders, MEDISCA recommends the Inversina mixer; a cost-effective solution allowing you to mix up to 2 L of powders.

Custom adapters can be developed in order to allow for mixing in different type of containers (pump bottles, syringes, etc.).

Milling: The MAZ mixer has particle sizing capability using milling media (Zirconium balls and cylinders). Preliminary results show a significant reduction in particle size from baseline measurements. For example, baseline Gabapentin had 90% of its distribution < 181 μm, 50% < 78 μm, and 10% < 18 μm. After 30 seconds of milling at half speed (1000 rpm), particle size was reduced to 83 μm , 14 μm, and 2 μm for 90%, 50%, and 10% distributions respectively. Additional data is currently being collected to determine optimal milling parameters.

Under maximum capacity and speed, at a distance of 1 m, the KK-300SS has an operating volume of approximately 65 dB. To put this in context, it is comparable to the volume of a verbal conversation.

Mixing: Creams, gels, ointments, liquids, and suspensions can all be mixed in 30 seconds at maximum speed (2,000 rpm), with minimal heat generation. For the KK-300SS, an operator would rarely use mixing times in excess of 2 minutes.

Deaeration: Cream, gels, and ointments can be deaerated in 1 minute at maximum speed (2,200 rpm), with minimal heat generation.

Melting: Gelatin Gum Base can be melted in 3 minutes.

Milling: Powder micronization can be achieved in 1 minute.

Mixing: A stability-indicating High Pressure Liquid Choromotography (HPLC) method was developed to determine the exact concentration of each API within different layers of the preparation.

Deaerating: Pycnometer measurements to confirm that the specific gravity of topical preparations can be restored after entrapped air is removed.

Milling: Quantitative measurements using the Malvern Mastersizer machine.

For smaller capacity units, the lead time is 5 business days if in stock. If model is out of stock, expect a 3-4 week lead time.

For larger capacity units, typical lead time is 4-6 weeks.

All mixing / deareating procedures should be performed using the mixing containers provided. Do not use any other jars, unless a custom adaptor is in use.

Yes, the MAZ mixer and mixing jar provides a closed system to mix all your preparations.

Yes, a video explaining features of the MAZ mixer along with a demo can be found on MEDISCA’s website. Specification sheets and brochures can also be downloaded from MEDISCA’s website.